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 Leucine in the sky with diamonds?

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thejpman

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MessageSujet: Leucine in the sky with diamonds?   Jeu 6 Jan - 1:19



Leucine being an essential amino acid cannot by synthesized by humans. New research is focusing heavily on leucine supplementation both to enhance muscle hypertrophy and to prevent muscle loss during weight loss.

Leucine does not only play a role as substrate for protein synthesis, but also as a signal nutrient that regulates protein metabolism. However, studies have found that leucine-rich amino acid mixtures are more effective than leucine alone in improving muscle mass and performance. This suggests that the efficacy or effectiveness of leucine depends on other amino acids (Balage et al, 2010).

Researchers at McMaster University have recently suggested (Little et al, 2010) the following:

“Based on results from acute and chronic studies in humans in a wide variety of wasting conditions, we propose that resistance exercise training combined with appropriately timed protein (likely leucine-rich) ingestion represents a highly effective means to promote muscle hypertrophy, and may represent a highly effective treatment strategy to counteract the muscle wasting associated with aging and chronic disease.”

Researchers at the University of Chicago have also suggested (Devkota et al, 2010):

“Leucine consumed at 2.5 g triggers a postmeal anabolic response that protects metabolic active tissues during weight loss and increases loss of body fat. SUMMARY: Balanced daily distribution of protein with increased intake at breakfast and lunch protects metabolically active tissues including skeletal muscle during weight loss.”

Key points made by Devota et al (2010):

“A growing body of research reveals that dietary intakes of protein above the minimum requirement designated as the recommended dietary allowance (RDA) are beneficial in treatment of diseases including obesity, metabolic syndrome, and type 2 diabetes.

We proposed that the beneficial effects of a higher-protein diet originate with the unique roles of the essential amino acid leucine in stimulating muscle protein synthesis, increasing diet-induced thermogenesis, enhancing satiety, and stabilizing glycemic regulations.”

Devota et al (2010) proposes that a minimum of a 2-3 times increase in plasma leucine is required to stimulate protein synthesis. To achive this effect, they suggest that humans need to consume a minimum of 25-30 g of protein containing a minimum of 2.5 g of leucine per meal. Different protein sources have varying percentages of leucine content by weight. The authors note that milk protein has 10% leucine content by weight while wheat proteins only have 6.8%. As such, they note that the quality of protein source for achieving this result is determined by the leucine content.

Bottom line: The importance of supplementation or consuming the essential amino acid, Leucine, appears to be attracting more attention from researchers with respect to its role in promoting protein synthesis and preventing muscle wasting during weight loss.

references:

Balage M, Dardevet D.Long-term effects of leucine supplementation on body composition.Curr Opin Clin Nutr Metab Care. 2010 May;13(3):265-70.
Little JP, Phillips SM. Resistance exercise and nutrition to counteract muscle wasting. Appl Physiol Nutr Metab. 2009 Oct;34(5):817-28.
Devkota S, Layman DK. Protein metabolic roles in treatment of obesity. Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):403-7.
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Louloubabar



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MessageSujet: Re: Leucine in the sky with diamonds?   Jeu 6 Jan - 2:10

J'adore le titre Very Happy
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thejpman

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MessageSujet: Re: Leucine in the sky with diamonds?   Jeu 6 Jan - 3:49

lol oui sympa tu nous la chante clin d\'oeil
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Louloubabar



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MessageSujet: Re: Leucine in the sky with diamonds?   Jeu 6 Jan - 9:25

Faut que je passe chez le coiffeur avant Very Happy
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umag

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MessageSujet: Re: Leucine in the sky with diamonds?   Sam 8 Jan - 13:56

Merci pour tous les articles.
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thejpman

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MessageSujet: Re: Leucine in the sky with diamonds?   Mar 24 Mai - 1:08

Leucine-Enriched Essential Amino Acid Drink After Exercise Increases Muscle Growth Genes

Research Updates





Leucine-Enriched Essential Amino Acid Drink After Exercise Increases Muscle Growth Genes

If you are looking to pack on some muscle size, you may want to consider adding an essential amino acid drink enriched with leucine after exercise. Researchers examined the anabolic effects of a leucine-enriched essential amino acid drink in young and old men after a bout of resistance exercise. Researchers took muscle biopsies to examine the expression anabolic and catabolic proteins. They found that even though the older and younger men performed the same workout (70 percent of 1 RM, 8 sets of 10 repetitions), young and older men had different genes being turned on after exercise. They found:



A protein called REDD2 (catabolic), which is a negative regulator of mTOR (a key anabolic pathway), was reduced in both younger and older men when they drank the leucine-enriched essential acid drink. This means leucine turns off catabolic genes. Good news for everyone!
A protein called Rheb (anabolic), which is a positive regulator of mTOR, was only increased in the young men who consumed the leucine-enriched essential acid drink. This means younger men have greater anabolic genes being turned on after exercise, compared to older men.
They also found IGF-1 levels increased only in the young, while the older men had no changes and also blunted satellite cell activity. Older men have a blunted muscle hypertrophy response to exercise; a decrease in IGF-1 seems to be a key cause.

The results of the study suggest that an essential amino acid drink enriched with leucine, which was designed to maximally stimulate protein synthesis, can benefit both older and younger men after resistance exercise, but older men lose key anabolic-signaling pathways compared to younger men.

Drummond MJ, Miyazaki M, Dreyer HC, Pennings B, Dhanani S, Volpi E, Esser KA, Rasmussen BB. Expression of growth-related genes in young and old human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol, 2008.
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Disiplin

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MessageSujet: Re: Leucine in the sky with diamonds?   Sam 13 Aoû - 16:18

De plus:
"The increment in MPS is maximally stimulated (Disiplin: Post exercise) at a dose of protein of approximately 25g or 10g EAA. (...). Leucine plays a key role in the stimulation of MPS and appears to be a key activator in switching on MPS, (...)."

"Thus, (...) whey protein would appear to be ideal candidates for stimulating MPS and promotion of hypertrophy"

Cet article dit que:
"(...) the dose of protein in younger men that maximally stimulate MPS was found to be approximately (...) 1.5g leucine"
Mais ils recommandent manger plus leucine que 1.5g

MPS = Muscle protein synthesis

EXERCISE AND PROTEIN NUTRITION. THE SCIENCE OF MUSCLE HYPERTROPHY: MAKING DIETARY PROTEIN COUNT (Nov 2010)
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shuikan

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MessageSujet: Re: Leucine in the sky with diamonds?   Sam 13 Aoû - 16:31

Vas te présenter merci .
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glutimus

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MessageSujet: Re: Leucine in the sky with diamonds?   Sam 13 Aoû - 17:52

T'as pas le meme genre d'article sur le HMB? Parceque depuis que j'essaye des trucs j'ai toujours l'impression que c'est de la poudre de perlinpinpin, autant le HMB ça me fait directement un effet.

Beta alanine aussi! Vais essayer de rajouter de la Leucine du coup.
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Leucine in the sky with diamonds?

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